Entity Address, City or Town
Entity Address, City or Town
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of reconciliation of the Company's expected federal income tax provision (benefit) to the actual income tax provision
Capitalized R&D expense
Deferred Tax Assets Capitalized RD expense
Deferred Tax Assets Capitalized RD expense.
Income Tax Examination, Year under Examination
Income tax examination, year under examination
Fair Value Disclosures [Abstract]
Earnings Per Share [Abstract]
Net Loss per Common Share [Abstract]
Scientific equipment.
Scientific Equipment [Member]
Scientific Equipment
Fair Value, Inputs, Level 1 [Member]
Quoted prices in Active Market for Identical Assets (Level 1)
Schedule of Accrued Liabilities [Table Text Block]
Schedule of accrued expenses
Lessee, Operating Lease, Option to Terminate
Option to terminate lease
Domestic Tax Authority [Member]
U.S. Federal
Stock Issued During Period, Value, New Issues
Public offering of common stock, net of offering costs
Aggregate purchase price of common stock
Aggregate value of stock issued to the collaborative partner during the period.
Stock Issued During Period Value To Collaborative Partner
Issuance of stock to collaboration partner, net of issuance costs
Research and Development Expense, Policy [Policy Text Block]
Research and Development Costs
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Outstanding at the end of the period
Number of stock shares issued to the collaborative partner during the period.
Stock Issued During Period Shares To Collaborative Partner
Issuance of stock to collaboration partner, net of issuance costs (in shares)
Amendment Flag
Amendment Flag
California institute for regenerative medicine .
California Institute For Regenerative Medicine [Member]
California Institute for Regenerative Medicine
Total fair value of awards vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Capital Expenditures Incurred but Not yet Paid
Purchases of property and equipment in accounts payable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Total fair value of stock options vested
Subsequent Event Type [Domain]
Subsequent Event Type
Other Long-Term Investments [Member]
Long-term Investments [Member]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Payments To Employees
Payments to Employees
Share-based Compensation arrangement by share-based payment award equity instruments other than options expected to vest weighted remaining contractual term.
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Remaining Contractual Term
Expected to vest at the end of the period
Collaborative arrangement aggregate payments receivable.
Collaborative Arrangement Aggregate Payments Receivable
Aggregate research and development fees payments receivable
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Right-of-use asset
Short-Term Investments [Abstract]
Corporate Restructuring
Corporate Restructuring [Member]
Corporate Restructuring [Member]
Option Exercise Payment
Option exercise payment.
Schedule of Long-Term Debt Instruments [Table]
Debt Instrument [Table]
Achievement of stock price appreciation milestone
Achievement of stock price appreciation milestone
Lessee operating lease cash rent period.
Lessee Operating Lease Cash Rent Period
Lease term
Increase decrease in right-of-use assets and lease liabilities, net.
Increase Decrease In Right Of Use Assets And Lease Liabilities Net
Right-of-use assets and lease liabilities, net
Fair Value Assumptions Expected Volatility Rate 1.
Fair Value Assumptions Expected Volatility Rate1
Expected volatility
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Common Share
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents
Statement [Table]
Statement [Table]
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Unrecognized tax benefits that, if recognized, would reduce the effective tax rate
Period for cumulative change in ownership.
Period For Cumulative Change In Ownership
Period of change in ownership
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Stock purchases under the plan (in shares)
Number of Operating Segments
Number of operating segments
London Interbank Offered Rate (LIBOR) [Member]
LIBOR
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred stock, outstanding shares
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for issuance
Auditor Firm ID
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Balance at the end of the period
Balance at the beginning of the period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Candidate two.
Candidate Two [Member]
Candidate 2
Minimum annual payments to maintain licenses.
Minimum Annual Payments To Maintain Licenses
Minimum annual payments to maintain licenses
Income Tax Authority [Domain]
Income Tax Authority
Product and Service [Axis]
Product and Service
Ono Letter Agreement.
Ono Letter Agreement [Member]
Ono Letter Agreement
Employee Stock Purchase Plan
Employee Stock [Member]
Collaboration services
Collaboration services
No definition available.
Collaboration And License Agreements Disclosure [Abstract]
Short-term leases term excluded from calculation of right of use of assets and lease liabilities.
Short Term Leases Term Excluded From Calculation Of Right Of Use Of Assets And Lease Liabilities
Short-term leases term excluded from calculation of ROU and lease liabilities
Lessee, Operating Leases [Text Block]
Leases
Stock price appreciation milestones, non current portion.
Stock Price Appreciation Milestones Liabilities Non Current
Stock price appreciation milestones, net of current portion
Share-Based Payment Arrangement, Option [Member]
Employee Stock Option
Operating Lease, Weighted Average Remaining Lease Term
Remaining weighted-average lease term
Liabilities and Equity
Total liabilities and stockholders’ equity
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Plan Name [Domain]
Plan Name
Percentage of number of employee reduced
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Income Statement [Abstract]
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Vested and expected to vest at the end of the period
Transaction price of agreement.
Transaction Price Of Agreement
Transaction price of the agreement
Investments [Abstract]
Represents the amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to permanent differences.
Income Tax Reconciliation Permanent Tax Differences
Permanent differences
Represents the monthly vesting period of share-based compensation awards.
Share Based Compensation Arrangement By Share Based Payment Award Monthly Award Vesting Period
Monthly vesting period
Fair Value, Assets, Level 1 to Level 2 Transfers, Amount
FairValueAssetsLevel1ToLevel2TransfersAmounts
FairValueAssetsLevel1ToLevel2TransfersAmounts
Deferred Revenue, Total
Deferred Revenue
Deferred revenue
Repayment percentage of award amount.
Repayment Percentage Of Award Amount
Repayment percentage of award amount
Sale of Stock [Domain]
Sale of Stock
Liabilities, Current
Total current liabilities
Number of disbursements receivable upon execution of award.
Number Of Disbursements Receivable Upon Execution Of Award
Number of disbursement receivable upon the execution of the award
Operating Loss Carryforwards, Total
Operating Loss Carryforwards
Net operating loss carryforwards
Expected ressarch services period.
Expected Ressarch Services Period
Expected ressarch services period
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Contract with Customer, Asset, after Allowance for Credit Loss, Noncurrent, Total
Contract with Customer, Asset, after Allowance for Credit Loss, Noncurrent
Collaboration contract asset
Collaboration contract assets
Fair Value, Recurring [Member]
Fair Value Measurements Recurring
Interest Expense, Total
Interest Expense
Interest expense
Amended MSK license member.
Amended M S K License [Member]
Amended MSK License
Short-Term Lease, Cost
Total short-term lease expense
Income Tax, Policy [Policy Text Block]
Income Taxes
Liquidity.
Liquidity Policy [Text Block]
Going Concern Assessment
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Other Noncurrent Assets [Member]
Non-current Assets [Member]
Deferred Tax Liabilities, Net
Net of deferred tax assets and liabilities
Deferred tax liabilities depreciation.
Deferred Tax Liabilities Depreciation
Depreciation
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease liabilities, weighted-average discount rate
Revenue, Product and Service [Extensible Enumeration]
Type of Revenue [Extensible List]
Variable Rate [Axis]
Variable Rate
Entity Small Business
Entity Small Business
Number of Reportable Segments
Number of reportable segments
Value of preferred share conversion to common stock.
Conversion Of Preference Share To Common Stock
Conversion of preferred shares to common stock
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Percentage of discretionary contributions description
Percentage of discretionary contributions description
Sublicense Consideration Represents an Asset Under ASC, Other Assets and Deferred Costs
Sublicense Consideration Represents an Asset Under ASC, Other Assets and Deferred Costs
Final payment fee on debt facility amount.
Final Payment Fee On Debt Facility Amount
Final payment fee
Investments [Domain]
Investments
Assets, Current
Total current assets
Property, Plant and Equipment [Line Items]
Property and equipment
Stock price appreciation milestone expense.
Stock Price Appreciation Milestone Expense
Stock price appreciation milestone, expense
Other than Temporary Impairment, Credit Losses Recognized in Earnings, Credit Losses on Debt Securities Held, Ending Balance
Other than Temporary Impairment, Credit Losses Recognized in Earnings, Credit Losses on Debt Securities Held, Beginning Balance
Other than Temporary Impairment, Credit Losses Recognized in Earnings, Credit Losses on Debt Securities Held
Available-for-sale securities, recognition of expected credit losses
Janssen Biotech Inc.
Janssen Biotech Inc [Member]
Janssen Biotech Inc
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
City Area Code
City Area Code
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding at the end of the period
Stock issued during period, shares, warrants exercised.
Stock Issued During Period Shares Warrants Exercised
Issuance of common stock upon cashless warrant exercise (in shares)
Regulatory and sales milestone payment
Regulatory And Sales Milestone Payment
Development, regulatory, and sales milestones
Milestone recorded to deferred revenue with remaining unrecognized revenue
Milestone Recorded to Deferred Revenue With Remaining Unrecognized Revenue
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Cancelled
Award agreement executed date.
Award Agreement Executed Date
Award agreement executed date
Silicon valley bank.
Silicon Valley Bank [Member]
Silicon Valley Bank
Private Placement [Member]
Private Placement
Document Period End Date
Document Period End Date
Payments of Stock Issuance Costs
Costs related to equity offering
Construction in Progress [Member]
Construction-in-Process
Investment maturity date range.
Investment Maturity Date Range
Maturity (in years)
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share of employee options granted
Lessee, Operating Lease, Renewal Term
Renewal term
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Software
Software and Software Development Costs [Member]
Contract with Customer, Liability, Noncurrent
Deferred revenue, net of current portion
Statistical Measurement [Axis]
Statistical Measurement
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Estimated Fair Value, Less Than 12 Months
Short-term investment maturity period range start.
Short Term Investment Maturity Period Range Start
Short term investments, maturity start range
Public equity offering.
Public Equity Offering Policy [Text Block]
Public Equity Offering
November 2016 placement.
November2016 Placement [Member]
November 2016 Placement
Assets
Total assets
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of preferred shares to common stock
State and Local Jurisdiction [Member]
California
September Twenty Twenty public equity offering member
June Twenty Twenty Public Equity Offering [Member]
June 2020 Public Offering
Earnings Per Share Diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Risks and uncertainties.
Risks And Uncertainties Policy [Text Block]
Risks and Uncertainties
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Anti-Dilutive Securities not Included in Calculation of Diluted Net Loss Per Common Share
Trailing stock price per share.
Trailing Stock Price Per Share
Ten-trading day trailing average common stock price
Dividends, Total
Dividends
Dividends declared
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Balance at the end of the period
Balance at the beginning of the period
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Document Fiscal Period Focus
Document Fiscal Period Focus
Represents information pertaining to 2013 Stock Option and Incentive Plan.
Stock Option And Incentive Plan2013 [Member]
Stock Option And Incentive Plan 2013
Restrictions on Cash and Cash Equivalents [Table Text Block]
Reconciliation of Cash, Cash Equivalents, and Restricted Cash
Office Equipment [Member]
Office Equipment
Increase (Decrease) in Accounts Receivable
Accounts receivable
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Valuation allowance
Preferred stock, $0.001 par value; authorized shares--5,000,000 at December 31, 2022 and December 31, 2021; Class A Convertible Preferred shares issued and outstanding--2,794,549 at December 31, 2022 and December 31, 2021
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock–based compensation
First-year research and development fees prepayment
Collaborative Arrangement First Year Research And Development Fees Prepayment
Collaborative arrangement first-year research and development fees prepayment.
Investment Income, Interest
Interest income
Counterparty Name [Domain]
Counterparty Name
Milestone Three Member.
Milestone Three [Member]
Milestone Three
Other income
Other Nonoperating Income
Operating Lease, Liability, Total
Operating Lease, Liability
Total lease liability
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted-Average Grant Date Fair Value per Share
Short-Term Debt, Type [Axis]
Short-term Debt, Type
Sensitivity percentage increase/decrease in stock price used as an input to measure fair value.
Fair Value Inputs Stock Price Sensitivity Percentage Increase Decrease
Sensitivity analysis fair value inputs stock price increase/decrease
Statement of Financial Position [Abstract]
Debt Security, Government, Non-US [Member]
Non-U.S. government securities
Entity File Number
Securities Act File Number
Income tax reconciliation nondeductible compensation.
Income Tax Reconciliation Nondeductible Compensation
Non-deductible compensation
Janssen agreement.
Janssen Agreement [Member]
Janssen Agreement
Statement of Cash Flows [Abstract]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Proceeds from Sale, Maturity and Collection of Investments, Total
Proceeds from Sale, Maturity and Collection of Investments
Maturities of investments
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of shares to be purchased
Retirement Benefits [Text Block]
Employee Benefits
Statistical Measurement [Domain]
Statistical Measurement
Statement of Stockholders' Equity [Abstract]
Sale of Stock [Axis]
Sale of Stock
Fair Value, Liabilities, Level 1 to Level 2 Transfers, Amount
FairValueLiabilitiesLevel1ToLevel2TransfersAmounts
FairValueLiabilitiesLevel1ToLevel2TransfersAmounts
Auditor Location
Class of Stock [Domain]
Class of Stock
Unrealized Gains
Debt Securities, Available-for-Sale, Unrealized Gain
Unrealized Gains
Stock price appreciation milestone liability.
Stock Price Appreciation Milestone Liability
Stock price appreciation milestone, liability
Amortization of sub license consideration.
Amortization Of Sub License Consideration
Amortization of sublicense consideration
Legal Entity
Legal Entity [Axis]
Lease, Cost [Table Text Block]
Schedule of Components of Lease Expense
Collaborative arrangement annual payments receivable recorded under deferred revenue.
Collaborative Arrangement Annual Payments Receivable Recorded Under Deferred Revenue
Collaborative arrangement annual payments receivable recorded as deferred revenue
Subsequent Events [Abstract]
Fair Value Disclosures [Text Block]
Fair Value Measurements
Repayments of debt including principal and final fee.
Repayments Of Debt Including Principal And Final Fee
Repayments of debt amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Exercisable at the end of the period
Proceeds from Stock Options Exercised
Issuance of common stock from equity incentive plans, net of issuance costs
Lease Agreements [Member]
The Premises 2020 Lease Agreement
Long-Term Debt, Type [Axis]
Long-term Debt, Type
Other Comprehensive Income (Loss), Tax [Abstract]
Other comprehensive loss:
Tax credit carryforward beginning expiration year.
Tax Credit Carryforward Beginning Expiration Year
Tax credit carryforward expiration year
Deferred Tax Assets, Tax Credit Carryforwards, Research
R&D tax credits
Period to treat award as grant, if award not treated as loan.
Period To Treat Award As Grant If Award Not Treated As Loan
Period to treat award as grant, if award not treated as loan
Property, Plant and Equipment [Table Text Block]
Schedule of property and equipment
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Common Stock Multiple
Common Stock Multiple1
Common stock multiple
Antidilutive Securities [Axis]
Antidilutive Securities
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value (in dollars per share)
Contract with Customer, Liability, Current
Deferred revenue, current portion
first Janssen Cancer Target
First Janssen Cancer Target [Member]
First Janssen Cancer Target
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Capitalized Contract Cost, Amortization
Amortization of collaboration contract asset
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Subsequent Events [Text Block]
Subsequent Events
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration agreement
Stock price appreciation milestones.
Stock Price Appreciation Milestones Policy [Text Block]
Stock Price Appreciation Milestones
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]
Organization and Summary of Significant Accounting Policies
Finite-Lived Intangible Assets, Major Class Name [Domain]
Finite-Lived Intangible Assets, Major Class Name
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State tax, net of federal tax benefit
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized compensation cost related to unvested restricted shares
Corporate Debt Securities [Member]
Corporate debt securities
Awards available under the 2022 Plan
Stock Option And Incentive Plan2022 [Member]
Stock Option And Incentive Plan2022 [Member]
Gladstone.
Gladstone [Member]
Gladstone
Computer Equipment [Member]
Computer Equipment
Severance and employee termination related costs - High range
High Range Restructuring Costs
High range restructuring costs.
General and Administrative Expense [Member]
General And Administrative
Convertible Preferred Stock, Shares Issued upon Conversion
Number of shares to be issued upon conversion
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation cost related to outstanding options
Commercial Paper [Member]
Commercial Paper
Current Fiscal Year End Date
Current Fiscal Year End Date
Investment Type [Axis]
Investment Type
Liability Class [Axis]
Liability Class
Financial Instruments [Domain]
Financial Instruments
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Total cash, cash equivalents, and restricted cash shown in the consolidated statement of cash flows
Cash, cash equivalents and restricted cash at beginning of the year
Cash, cash equivalents and restricted cash at end of the year
Accrued clinical trial related costs current.
Accrued Clinical Trial Related Costs Current
Accrued clinical trial related costs
Other Assets, Noncurrent, Total
Other Assets, Noncurrent
Other assets
Entity Address, Address Line One
Entity Address, Address Line One
The cash inflow from the additional capital contribution to the entity in connection with a collaboration agreement.
Proceeds From Issuance Of Common Stock In Connection With Collaboration Agreement
Proceeds from sale of common stock to collaboration partner, net of issuance costs
Document Annual Report
Document Annual Report
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets by Major Class
Straight Line Rent Adjustments
Straight-line lease expense
Accrued Liabilities, Current [Abstract]
Current accrued expenses
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow information
Warrants exercise terms description.
Warrants Exercise Terms Description
Terms of exercise
Investment, Policy [Policy Text Block]
Investments
Components of Deferred Tax Assets [Abstract]
Deferred tax assets:
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Investments
Employee and Non Employee Stock Option
Represents an arrangement whereby both an employee and a non-employee is entitled to receive in the future, subject to vesting and other restrictions, certain number of shares in the entity at a specified price, as defined in the agreement.
Employee And Non Employee Stock Option [Member]
Stock price decreased by ten percent per share.
Stock Price Decreased By Ten Percent Per Share [Member]
Stock price decreased by 10% per share
Restricted Cash, Noncurrent
Restricted cash
Income Tax Expense (Benefit)
Income tax expense
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Valuation allowance
Income tax reconciliation reserve for uncertain tax positions.
Income Tax Reconciliation Reserve For Uncertain Tax Positions
Reserve for uncertain tax positions
Income Tax Disclosure [Text Block]
Income Taxes
Preferred Stock, Shares Issued, Total
Preferred Stock, Shares Issued
Preferred stock, issued shares
Balance Sheet Location [Domain]
Balance Sheet Location
Other Accrued Liabilities, Current
Accrued other
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Purchase price of prefunded warrants.
Purchase Price Of Prefunded Warrants
Purchase price of prefunded warrants
Income Tax Disclosure [Abstract]
Income Taxes
Johnson & Johnson Innovation-JJDC, Inc.
Johnson Johnson Innovation J J D C Inc [Member]
Johnson Johnson Innovation J J D C Inc
Research services.
Research Services [Member]
Research services
Upfront non-refundable non-creditable payment receivable.
Upfront Non Refundable Non Creditable Payment Receivable
Non-refundable upfront payments recorded as deferred revenue
Collaborative Arrangement [Member]
Collaborative Arrangement
Stock Issued During Period, Shares, New Issues
Public offerings of common stock, net of offering costs (in shares)
Common stock issued
CIRM award liability, noncurrent.
C I R M Award Liability Noncurrent
CIRM award liability, net of current portion
Fair Value Assumptions Expected Term 1.
Fair Value Assumptions Expected Term1
Estimated term (in years)
Assets, Fair Value Disclosure [Abstract]
Financial assets:
One-time option to terminate the lease, subject to certain termination payment.
Early Termination Fee
Early termination fees
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Auditor Name
Employee Retention credit
Employee Retention Credit Policy
Employee Retention Credit Policy
Recognize remaining amount of deferred revenue
Contract with Customer, Liability, Revenue Recognized
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Cancelled
Operating Income (Loss)
Loss from operations
Debt Instrument, Interest Rate, Stated Percentage
Award considered as a loan, interest rate
Lessee, Operating Lease, Option to Extend
Lessee, operating lease, option to extend
California Franchise Tax Board [Member]
Californian
Equity premium.
Equity Premium
Equity premium
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Debt Securities, Available-for-Sale, Unrealized Loss Position
Estimated Fair Value, Total
Estimated Fair Value, Total
Class of Warrant or Right [Domain]
Class of Warrant or Right
Entity Filer Category
Entity Filer Category
Tenant Improvements
Tenant improvements
Stock purchase agreement [Member].
Stock Purchase Agreement [Member]
Stock Purchase Agreement
Operating Expenses
Total operating expenses
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Entity Current Reporting Status
Entity Current Reporting Status
Stock Issued During Period, Value, Restricted Stock Award, Gross
Issuance of common stock upon vesting of restricted stock units
Asset Class [Domain]
Asset Class
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock compensation
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Exercisable at the end of the period
Stockholders' Equity Note Disclosure [Text Block]
Convertible Preferred Stock and Stockholders’ Equity
Stockholders' Equity Attributable to Parent
Balance
Balance
Total stockholders’ equity
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss
Unrealized Losses, Total
Unrealized Losses, Total
Unrealized Losses, Total
Share based compensation arrangement by share based payment award annually award vesting period.
Share Based Compensation Arrangement By Share Based Payment Award Annually Award Vesting Period
Annually vesting period
Debt Securities, Available-for-sale, Realized Gain (Loss), Total
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Available-for-sale securities, realized gains (losses) on sales
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Gain (Loss)
Short-Term Investments [Member]
Short-term Investments [Member]
Asset Class [Axis]
Asset Class
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Milestone Two Member.
Milestone Two [Member]
Milestone Two
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement Location [Axis]
Income Statement Location
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Cancelled
Common stock, $0.001 par value; authorized shares--250,000,000 at December 31, 2022 and December 31, 2021; issued and outstanding --97,294,917 at December 31, 2022 and 95,726,962 at December 31, 2021
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Unrealized (loss) gain on available-for-sale securities, net
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Equity Components [Axis]
Equity Components
Maximum percentage of common stock ownership together with affiliates allowable after exercise of prefunded warrants.
Maximum Percentage Of Common Stock Ownership Together With Affiliates Allowable After Exercise Of Prefunded Warrants
Maximum percentage of common stock ownership together with affiliates allowable after exercise of prefunded warrants
Accrued Expenses and Long-Term Debt
The entire disclosure for accrued expenses and long-term debt.
Accrued Expenses And Long Term Debt [Text Block]
Proceeds from CIRM award.
Proceeds From C I R M Award
Proceeds from CIRM award
Leases [Abstract]
Contract with Customer, Liability, Total
Contract with Customer, Liability
Milestone payments recorded to deferred revenue
Milestone payments during the period.
Milestone Payments
Stock price appreciation milestone payment
Milestone payments
Convertible preferred stock and stockholders' equity.
Convertible Preferred Stock And Stockholders Deficit Disclosure [Abstract]
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Accounts payable and accrued expenses
Entity Emerging Growth Company
Entity Emerging Growth Company
Related Party Transaction [Axis]
Related Party Transaction
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss
Unrealized Losses, 12 Months or Greater
Unrealized Losses, 12 Months or Greater
Operating Expenses [Abstract]
Operating expenses:
Interest Expense, Debt, Total
Interest Expense, Debt
Aggregate interest expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Vested and expected to vest at the end of the period
Ono Pharmaceutical Company Ltd.
Ono Pharmaceutical Company Ltd [Member]
Ono Pharmaceutical Company Ltd
Revenue [Policy Text Block]
Revenue Recognition
Amended and Restated Exclusive License Agreement.
Amended And Restated Exclusive License Agreement [Member]
Amended MSK License
Milestone achievement payment
Milestone achievement payment
Letter of Credit [Member]
Letter of Credit
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Number of employee reduced
Restructuring And Related Cost Number Of Positions Retained
Restructuring and related cost number of positions retained.
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Payments to Acquire Investments, Total
Payments to Acquire Investments
Purchases of investments
Entity Voluntary Filers
Entity Voluntary Filers
Research Tax Credit Carryforward [Member]
Research and development
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Weighted Average Remaining Contractual Term
Retirement Benefits [Abstract]
Document Transition Report
Document Transition Report
Operating Leases, Rent Expense, Total
Operating Leases, Rent Expense
Aggregate contractual rent expense
Total assets measured at fair value on a recurring basis
Assets, Fair Value Disclosure
Total assets measured at fair value on a recurring basis
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted
Depreciation, Depletion and Amortization, Total
Depreciation, Depletion and Amortization
Depreciation expense
Depreciation and amortization
Income Tax Uncertainties [Abstract]
Represents the amount of upfront payments received under collaborative arrangements is recorded as deferred revenue.
Collaborative Arrangements Upfront Payments Recorded Under Deferred Revenue
Non-refundable upfront payments recorded as deferred revenue
Sale of Stock, Price Per Share
Common stock per share
Collaborative Arrangement Disclosure [Text Block]
Collaboration and License Agreements
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
CIRM award liability current.
C I R M Award Liability Current
CIRM award liability, current portion
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Restricted Stock Units
Accumulated other comprehensive (loss) gain
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Additional Cancer Targets.
Additional Cancer Targets [Member]
Additional Cancer Targets
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable
Preferred stock conversion price.
Preferred Stock Conversion Price
Conversion price
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Collaborative arrangement terminate upon receipt of research payment.
Collaborative Arrangement Terminate Upon Receipt Of Research Payment
Agreement to terminate upon the receipt of research payment
Net Income (Loss) Attributable to Parent
Net loss
Net loss
Operating Lease, Liability, Current
Operating lease liabilities, current portion
Number of disbursements receivable based on completion of certain operating milestones.
Number Of Disbursements Receivable Based On Completion Of Certain Operating Milestones
Number of disbursements receivable based on completion of certain operating milestones
September Twenty Nineteen public equity offering.
September Twenty Nineteen Public Equity Offering [Member]
September 2019 Public Equity Offering
Share-based Compensation arrangement by share-based payment award equity instruments other than options expected to vest aggregate intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Aggregate Intrinsic Value
Restricted stock units expected to vest at December 31, 2021
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating losses
Maximum percentage of common stock ownership after change upon notice.
Maximum Percentage Of Common Stock Ownership After Change Upon Notice
Maximum percentage of common stock ownership after change upon notice.
Redmile Group, LLC and Affiliates.
Redmile Group Limited Liability Company And Affiliates [Member]
Redmile Group, LLC and Affiliates
Prepaid expenses and other assets.
Prepaid Expenses And Other Assets [Member]
Prepaid Expenses And Other Assets
Entity Registrant Name
Entity Registrant Name
Liabilities, Fair Value Disclosure, Total
Liabilities, Fair Value Disclosure
Total financial liabilities measured at fair value on a recurring basis
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of weighted-average assumptions used to determine the fair value of employee and nonemployee stock option grants
Class of Stock [Axis]
Class of Stock
September Twenty Eighteen public equity offering.
September Twenty Eighteen Public Equity Offering [Member]
September 2018 Public Equity Offering
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Award agreement for research and development disclosure.
Award Agreement For Research And Development Disclosure [Text Block]
California Institute for Regenerative Medicine Award
Pre-Funded Warrants.
Pre Funded Warrants [Member]
Pre-Funded Warrants
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Award Type [Domain]
Award Type
Statement [Line Items]
Statement [Line Items]
Other Income
Other Income
Financial liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Title of 12(b) Security
Title of 12(b) Security
Stock price appreciation milestone.
Stock Price Appreciation Milestones [Member]
Stock price appreciation milestones
Common Stock [Member]
Common Stock
Sale of Stock, Consideration Received on Transaction
Net proceeds from issuance of shares after related cash costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Term of stock awards
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents and Restricted Cash
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating activities:
Represents the agreed term of research under collaborative arrangements.
Collaborative Arrangement Term Of Research
Research term
Equity Component [Domain]
Equity Component
Fair Value Measurement, Policy [Policy Text Block]
Fair Value of Financial Instruments
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Class A Convertible Preferred Shares
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration revenue
Revenue recognized
Debt instrument repayment phase four rate.
Debt Instrument Repayment Phase Four Rate [Member]
Loan Repayment Rate Four
Entity Address, State or Province
Entity Address, State or Province
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Upfront fee.
Upfront Fee [Member]
Upfront Fee
Collaborative arrangement percentage of reduction on milestone payments.
Collaborative Arrangement Percentage Of Reduction On Milestone Payments
Percentage of reduction on milestone payments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Vested and expected to vest at the end of the period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net change in cash, cash equivalents and restricted cash
Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest
Comprehensive loss
Document Type
Document Type
Interest Paid, Excluding Capitalized Interest, Operating Activities
Interest paid
Proceeds from Collaborators
Receipt of first disbursement under the Award
Sensitivity analysis share price fair value input.
Share Price Fair Value Input
Sensitivity analysis share price fair value input
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
R&D tax credits
Entity Shell Company
Entity Shell Company
Stock-based compensation
Share-Based Payment Arrangement, Expense
Total stock-based compensation expense
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Memorial Sloan Kettering Cancer Center.
Memorial Sloan Kettering Cancer Center [Member]
MSK
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Assets, Level 2 to Level 1 Transfers, Amount
FairValueAssetsLevel2ToLevel1TransfersAmounts
FairValueAssetsLevel2ToLevel1TransfersAmounts
Security Exchange Name
Security Exchange Name
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Schedule of milestone payments valuation assumptions table text block.
Schedule Of Milestone Payments Valuation Assumptions Table [Text Block]
Schedule of Assumptions Used to Determine the Estimated Fair Value of the Stock Price Appreciation Milestone Payments
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Expected recognition period of unrecognized compensation cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Outstanding at the end of the period
Gladstone license agreement.
Gladstone License Agreement [Member]
Gladstone License Agreement
Award from regenerative medicine institute.
Award From Regenerative Medicine Institute [Table]
Award From Regenerative Medicine Institute [Table]
Commitments and Contingencies Disclosure [Abstract]
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
Net operating loss carryforward expiration year
Operating Lease, Cost
Total operating lease expense
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units (RSUs)
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of Future Minimum Payments Under Non-cancelable Operating Leases
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Summary of the change in the Company's unrecognized tax benefits
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Collaboration agreement expiration date.
Collaboration Agreement Expiration Date
Collaboration agreement expiration date
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of restricted stock unit activity and related information under all equity plans
Severance and employee termination related costs - Low range
Low Range Restructuring Costs
Low range restructuring costs.
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted and Issued Accounting Pronouncements
Debt instrument repayment phase three rate.
Debt Instrument Repayment Phase Three Rate [Member]
Loan Repayment Rate Three
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding
Common stock, outstanding shares
Profit loss sharing percentage.
Profit Loss Sharing Percentage
Profits and losses sharing percentage
Accretion (Amortization) of Discounts and Premiums, Investments
Accretion and amortization of premiums and discounts on investments, net
Fair Value, Inputs, Level 2 [Member]
Significant Other Observable Inputs (Level 2)
Deferred Revenue, Current, Total
Deferred Revenue, Current
Deferred revenue classified as current
Milestone Receivable Shows an Increase in the Initial Transaction Price
Milestone Receivable Shows an Increase in the Initial Transaction Price
Estimated Fair Value
Debt Securities, Available-for-Sale
Estimated Fair Value
Estimated Fair Value
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing activities
Stock issued during period, value, warrants exercised.
Stock Issued During Period Value Warrants Exercised
Issuance of common stock upon cashless warrant exercise
Stock price appreciation milestone, income
StockPriceAppreciationMilestoneIncome
StockPriceAppreciationMilestoneIncome
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increase related to current year tax positions
Commitments and Contingencies
Commitments and contingencies
Income Tax Authority, Name [Domain]
Income Tax Authority, Name
Common stock, issued shares
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
US Treasury Securities [Member]
U.S. Treasury debt securities
Treasuries, Commercial paper. Non US government securities and Corporate Debt Securities
Variable Rate [Domain]
Variable Rate
Minimum [Member]
Minimum
Common stock of public offering and issuance of pre funded warrants.
Common Stock Of Public Offering And Issuance Of Pre Funded Warrants
Public offering of common stock and issuance of pre-funded warrants, net of offering costs (in shares)
Income Tax Authority, Name [Axis]
Income Tax Authority, Name
Stock price appreciation milestone payable.
Stock Price Appreciation Milestone Payable
Stock price appreciation milestone payable
Variable Interest Entity, Measure of Activity [Abstract]
Milestone one member.
Milestone One [Member]
Milestone One
Stock Issued During Period, Value, Issued for Services
Issuance of common stock for license agreements
Issuance of common stock for license agreements
Lessee, Leases [Policy Text Block]
Leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Exercisable at the end of the period
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Accrued Liabilities, Current
Accrued expenses
Total current accrued expenses
Represents the amount of an unrecognized tax benefit that is directly related to a position taken in a tax year, which results in a net operating loss and tax credit carryforward.
Unrecognized Tax Benefits Resulting In Net Operating Loss And Tax Credit Carryforward
Unrecognized tax benefit
Debt Instrument [Axis]
Debt Instrument
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders’ equity:
Schedule of Available-for-Sale Securities [Table]
Schedule Of Available For Sale Securities [Table]
Counterparty Name [Axis]
Counterparty Name
Entity Address, Address Line Two
Entity Address, Address Line Two
Restricted Cash and Cash Equivalents, Noncurrent, Total
Restricted Cash and Cash Equivalents, Noncurrent
Restricted cash
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents
January Two Thousand Twenty One Public Equity Offerings.
January Two Thousand Twenty One Public Equity Offerings [Member]
January 2021 Public Equity Offering
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Cancelled
Enterprise value milestones liability at fair value
Enterprise Value Milestones Liability At Fair Value
Enterprise Value Milestones Liability At Fair Value.
Award Type [Axis]
Award Type
Subsequent Event [Member]
Subsequent Event
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities.
Deferred Tax Assets Lease Liabilities
Lease liability
Related Party Transaction [Domain]
Related Party Transaction
Deferred Tax Assets, Gross
Total deferred tax assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of stock options exercised
Warrants for common stock.
Warrants For Common Stock [Member]
Warrants For Common Stock
Other Nonoperating Income (Expense)
Total other income (expense), net
Proceeds from Issuance of Private Placement
Proceeds from private placement of common stock, net of issuance costs
Fair Value, Liabilities, Level 2 to Level 1 Transfers, Amount
FairValueLiabilitiesLevel2ToLevel1TransfersAmounts
FairValueLiabilitiesLevel2ToLevel1TransfersAmounts
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Research and Development Expense, Total
Research and Development Expense
Research and development
Lessee, Operating Lease, Liability, to be Paid
Future minimum payments under the operating leases
Total undiscounted lease payments
Restructuring Type [Axis]
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decrease related to prior year tax positions
Lessee, Operating Lease, Term of Contract
Lease term
Additional candidate milestone payment.
Additional Candidate Milestone Payment
Additional candidate milestone Payments
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible asset amortization
Entity Central Index Key
Entity Central Index Key
Stock purchase agreement axis.
Stock Purchase Agreement [Axis]
Stock Purchase Agreement
Award from regenerative medicine institute.
Award From Regenerative Medicine Institute [Abstract]
Short-term investments
Short-Term Investments
Short-Term Investments, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Weighted-average assumptions to determine fair value of stock options
Debt Securities, Available-for-Sale [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Interest Receivable
Accured Interest on investments
Investment Holdings, Schedule of Investments [Table Text Block]
Aggregated by investment category and the length of time
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation and amortization
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Addtional Amount Available For Funding Under Award
Additional amount available for funding under award
Addtional Amount Available For Funding Under Award
Addtional amount available for funding under award.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Outstanding at the end of the period (in dollars)
Measurement Frequency [Axis]
Measurement Frequency
Equity premium on share price per share under agreement.
Equity Premium On Share Price Per Share Under Agreement
Equity premium per share
Subsequent Event [Table]
General and Administrative Expense, Total
General and Administrative Expense
General and administrative
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and summary of significant accounting policies
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Balance at the end of the period
Balance at the beginning of the period
Preferred Class A [Member]
Non-Voting Class A Preferred Stock
Research and Development Expense [Member]
Research And Development
Fair Value, Nonrecurring [Member]
Fair Value Measurements Nonrecurring
Public offering of common stock and issuance of pre-funded warrants.
Public Offering Of Common Stock And Issuance Of Pre Funded Warrants
Public offering of common stock and issuance of pre-funded warrants, net of offering costs
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets obtained in exchange for lease obligations
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities
Retained Earnings [Member]
Accumulated Deficit
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Candidate 1
Candidate One [Member]
Candidate one.
Stock price appreciation milestones.
Stock Price Appreciation Milestones
Stock price appreciation milestones
Money Market Funds [Member]
Money market funds
Aggregate equity premium on shares issued under agreement.
Aggregate Equity Premium On Shares Issued Under Agreement
Aggregate equity premium on shares
Stock price increased by ten percent per share.
Stock Price Increased By Ten Percent Per Share [Member]
Stock price increased by 10% per share
Share-based Compensation arrangement by share-based payment award equity instruments other than options expected to vest number.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Number
Expected to vest at the end of the period
Cumulative change in ownership percentage.
Cumulative Change In Ownership Percentage
Cumulative changes in ownership percentage
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross
Property and equipment, gross
Disclosure of accounting policy for private placement of common stock.
Private Placement Of Common Stock Policy Policy [Text Block]
Private Placements of Common Stock
Percentage Of Tax Credit
Percentage of Tax Credit
Percentage of Tax Credit
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Stock options generally vested on anniversary grant date (as a percent)
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Total
Additional Paid in Capital
Additional paid-in capital
Entity Interactive Data Current
Entity Interactive Data Current
Tax Credit Carryforward, Amount
Tax credit carryforwards
Loan Repayment Rate Two
Debt instrument repayment phase two rate.
Debt Instrument Repayment Phase Two Rate [Member]
Entity Public Float
Entity Public Float
Performance-based restricted granted, none of vested Units Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Letters of Credit Outstanding, Amount
Letters of credit outstanding amount
Letters of credit outstanding amount
Temporary Equity [Line Items]
Convertible preferred stock
Sublicense consideration.
Sublicense Consideration [Member]
Sublicense Consideration
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental schedule of noncash investing and financing activities
Amount of deferred tax liability attributable to taxable temporary differences from right-of-use assets.
Deferred Tax Liabilities Right Of Use Assets
Right-of-use assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Leasehold improvements-building
Leasehold Improvements [Member]
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Accrued issuance costs included in additional paid-in-capital
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Estimated Fair Value, 12 Months or Greater
Proceeds from issuance of pre-funded warrants, net of issuance costs
Proceeds from Issuance of Warrants
Local Phone Number
Local Phone Number
Unrecognized Tax Benefits
Ending unrecognized tax benefits
Beginning unrecognized tax benefits
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Assets Measured at Fair Value on Recurring Basis
Operating loss carryforwards indefinite life.
Operating Loss Carryforwards Indefinite Life
Operating loss carryforwards indefinite life
Represents minimum age of employees to become eligible for participation under defined contribution plans.
Defined Contribution Plan Minimum Age Of Employee
Minimum age of employees
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Reconciliation of the Company's expected federal income tax provision (benefit) to the actual income tax provision
Collaboration Agreement
Collaboration Agreement [Member]
Collaboration Agreement [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
General vesting period after first year
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stockholders' Equity
Represents the name of the counter party with whom the company entered into agreement
Juno Therapeutics Inc [Member]
Juno Therapeutics, Inc
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Exercisable at the end of the period
Percentage of common stock ownership upon preferred stock conversion.
Percentage Of Common Stock Ownership Upon Preferred Stock Conversion
Percentage of common stock ownership upon preferred stock conversion
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lessee, operating lease, existence of option to extend
Corresponding asset for sublicense consideration paid.
Corresponding Asset For Sublicense Consideration Paid
Sublicense consideration paid
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Components of Deferred Tax Liabilities [Abstract]
Deferred tax liabilities:
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Summary of Changes in the Fair Value of the Company’s Level 3 Enterprise Fair Value Milestone Payment Liability
Fair Value Measurement Inputs and Valuation Techniques [Abstract]
Determine the estimated fair value of the enterprise value milestone payments
Other Current Assets [Member]
Current Assets [Member]
Upfront payments.
Upfront Payments
Upfront cash payment
Enterprise value milestone payment.
Enterprise Value Milestone Payment
Stock price appreciation milestones potential payments
Income Statement Location [Domain]
Income Statement Location
Number of employee reduced
Restructuring and Related Cost, Number of Positions Eliminated
Property, Plant and Equipment [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Balance at the end of the period
Balance at the beginning of the period
Proceeds From Research and Development Fees Received.
Proceeds From Research And Development Fees Received
Research and development fees cash payments received
Award From California Institute For Regenerative Medicine [Abstract]
Award from the california institute for regenerative medicine.
Award From California Institute For Regenerative Medicine [Abstract]
Shares, Outstanding
Balance (in shares)
Balance (in shares)
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Balance at the end of the period
Balance at the beginning of the period
Share Price
Closing stock price as of measurement date
Debt Instrument, Name [Domain]
Debt Instrument, Name
Document Fiscal Year Focus
Document Fiscal Year Focus
Common stock issued during period shares private placement.
Common Stock Issued During Period Shares Private Placement
Private placement of common stock, net of issuance costs (in shares)
Common stock multiples and the enterprise value milestone payments.
Common Stock Multiples And The Enterprise Value Milestone Payments Table [Text Block]
Summary of All Possible Stock Price Appreciation Milestone Payments
Class of Warrant or Right [Axis]
Class of Warrant or Right
Award for first-in-human clinical trial.
Award For First In Human Clinical Trial
Award for first-in-human clinical trial
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Earnings Per Share, Basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Loan and security agreement.
Loan And Security Agreement [Member]
Loan and Security Agreement
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted-Average Price
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Table]
Payments for Tenant Improvements
Aggregate tenant improvements of the premises
Assets [Abstract]
Assets
Employees and Directors stock options.
Employees And Directors Stock Options [Member]
Employee and Directors Stock Option
Employee Retention Credit [Member]
Employee Retention Credit [Member]
Conversion of preferred shares to common stock, shares
Conversion Of Preferred Shares To Common Stocks Shares
Conversion of preferred shares to common stock (in shares)
Debt Instrument, Annual Principal Payment
Principal amount of the final fee payment
Deferred Tax Assets, Net
Net deferred tax assets
RefundableTaxCredit
Refundable Tax Credit
Refundable Tax Credit
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Collaborative arrangement annual payments received.
Collaborative Arrangement Annual Payments Received
Payments for research and development fees
Represents the percentage of additional shares authorized for issuance under an established share-based compensation plan as a proportion of outstanding capital stock.
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Additional Shares Authorized
Additional shares authorized (as a percent)
Shares Issued, Price Per Share
Share issue price (in dollars per share)
Share-Based Payment Arrangement [Member]
Stock Compensation Plan
Common Stock Options
Series A Preferred Stock [Member]
Series A Convertible Preferred Stock (if converted)
Convertible Preferred Stock (if converted)
Financial Instrument [Axis]
Financial Instrument
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Deferred Tax Assets, Deferred Income
Deferred revenue
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Number of Options
Debt instrument repayment phase one rate.
Debt Instrument Repayment Phase One Rate [Member]
Loan Repayment Rate One
Liabilities and Equity [Abstract]
Liabilities and Stockholders’ Equity
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Stock purchase agreement domain.
Stock Purchase Agreement [Domain]
Stock Purchase Agreement
Inducement plan.
Inducement Plan [Member]
Inducement Plan
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Income Tax Authority [Axis]
Income Tax Authority
Type of Restructuring [Domain]
Preferred Stock [Member]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Award from regenerative medicine institute.
Award From Regenerative Medicine Institute [Line Items]
Award from California institute for regenerative medicine
Assets, Current [Abstract]
Current assets:
Tabular disclosure of the common stock reserved for future issuance.
Schedule Of Common Stock Reserved For Future Issuance Table [Text Block]
Schedule of common stock reserved for future issuance
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price of warrants
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Summary of significant components of the Company's deferred tax assets
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss
Unrealized Losses, Less Than 12 Months
Unrealized Losses, Less Than 12 Months
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Increase related to prior year tax positions
Increase related to prior year tax positions
Measurement Frequency [Domain]
Measurement Frequency
Fair Value Assumptions Risk Free Interest Rate 1.
Fair Value Assumptions Risk Free Interest Rate1
Risk-free interest rate
Upfront fee and equity premium.
Upfront Fee And Equity Premium [Member]
Upfront Fee and Equity Premium
Increase (Decrease) in Operating Capital [Abstract]
Changes in assets and liabilities:
Lease, Cost [Abstract]
Entity
Entity [Domain]
Convertible preferred stock.
Convertible Preferred Stock Policy [Text Block]
Convertible Preferred Stock
Increase decrease in fair value of stock price appreciation milestones.
Increase Decrease In Fair Value Of Stock Price Appreciation Milestones
Change in fair value of stock price appreciation milestones
Change in fair value of stock price appreciation milestones
Accrued Salaries, Current
Accrued payroll and other employee benefits
Cover [Abstract]
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Total
Other-than-temporary Impairment Loss, Debt Securities, Available-for-Sale
Available-for-sale securities, impairment
Product and Service [Domain]
Product and Service
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Change in the Company's unrecognized tax benefits
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Percent of taxable income offset.
Percent Of Taxable Income Offset
Percent of taxable income offset
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested
Liabilities, Current [Abstract]
Current liabilities:
Stock issued during period shares for private placement
Stock Issued During Period Shares For Private Placement
Issuance of common stock during period for private placements (in shares)
Percentage of common stock ownership for preferred stock conversion change upon notice.
Percentage Of Common Stock Ownership For Preferred Stock Conversion Change Upon Notice
Preferred shares converted into common stock percentage of ownership change upon notice
Maximum [Member]
Maximum
Disclosure of accounting policy for patent costs.
Patent Costs Policy [Text Block]
Patent Costs
Unrealized loss on investments, net
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of allocation of stock-based compensation for all stock awards
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Furniture and Fixtures [Member]
Furniture And Fixtures
Proceeds from public offering of common stock, net of issuance costs
Proceeds from Public Offering of Common Stock and Issuance of Pre-Funded Warrants
The cash inflow associated with the amount received.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of stock options, net of issuance costs (in shares)
Exercised
Common Stock, Value, Outstanding
Aggregate value of common stock
Fair Value, Inputs, Level 3 [Member]
Significant Unobservable Inputs (Level 3)
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Issuance of common stock upon vesting of restricted stock units (in shares)
Share-based Compensation arrangement by share-based payment award equity instruments other than options expected to vest weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value
Expected to vest at the end of the period
Collaborative arrangement aggregate milestone payments receivable.
Collaborative Arrangement Aggregate Milestone Payments Receivable
Aggregate milestone payments
Common stock issued during period value private placement.
Common Stock Issued During Period Value Private Placement
Private placement of common stock, net of issuance costs
Deferred Tax Liabilities, Gross, Total
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Stock Issued During Period, Shares, Issued for Services
Issuance of common stock for license agreements (in shares)
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options, net of issuance costs
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Accrued expenses and long term debt disclosure.
Accrued Expenses And Long Term Debt Disclosure [Abstract]
Long-term Investments, Total
Long-Term Investments
Long-term investments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Vested and expected to vest at the end of the period
Property, Plant and Equipment, Useful Life
Estimated useful lives
Defined Contribution Plan, Cost
Matching contributions under 401(k) plan
Preferred Stock, Convertible, Terms
Terms of conversion
Common stock capital additional shares reserved for future issuance.
Common Stock Capital Additional Shares Reserved For Future Issuance
Additional shares reserved for issuance
Common Stock, Shares Authorized
Common stock, authorized shares
Short-Term Debt, Type [Domain]
Short-term Debt, Type
Trading Symbol
Trading Symbol
Schedule of Stock Options Roll Forward [Table Text Block]
Summary of stock option activity and related information under all equity plans
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Investments
Municipal Notes [Member]
Municipal securities
Title of Individual [Domain]
Title of Individual
Subsequent Event Type [Axis]
Subsequent Event Type
Deferred Tax Assets, Other
Other
Upfront, non-refundable and non-creditable payment.
Upfront Non Refundable And Non Creditable Payment
Upfront, non-refundable and non-creditable payment
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Additional Disclosures [Abstract]
Weighted Average Remaining Vesting Period
Balance Sheet Location [Axis]
Balance Sheet Location
FT516.
F T Five One Six [Member]
FT516
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk–free interest rate
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Plan Name [Axis]
Plan Name
Title of Individual [Axis]
Title of Individual
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Tax computed at federal statutory rate
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Collaborative Arrangements
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Common Stock, Par or Stated Value Per Share
Common stock, par value (in dollars per share)
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Number of disbursements.
Number Of Disbursements
Number of disbursements
Income Tax Examination, Likelihood of Unfavorable Settlement
Uncertain tax position description
Represents information pertaining to computer and office equipment.
Computer And Office Equipment [Member]
Computer And Office Equipment
Short-term investment maturity period range end.
Short Term Investment Maturity Period Range End
Short term investments, maturity end range
Variable Lease, Cost
Variable lease expense
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Performance stock, granted
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Additional shares authorized
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Long-Term Debt, Type [Domain]
Long-term Debt, Type
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities (in shares)
Cash and Cash Equivalents, Fair Value Disclosure
Money market funds
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Line Items]
Collaborative arrangement potential additional milestones.
Collaborative Arrangement Potential Additional Milestones
Collaborative arrangement potential additional milestones